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Discover how Real-World Data Accelerates Clinical Trial Completion
Clinical trials often falter at the final stretch—when it’s time to execute. It’s here that well-intentioned protocols meet real-world complexity, where timelines can slip, costs may surge, and outcomes could fall short of expectations.
The Hidden Cost of Misaligned Trial Design
%
Of protocols undergo at least one substantial amendment
Of these amendments are deemed “avoidable”
%
Median direct cost to implement a substantial amendment for a phase III protocol
TriNetX: Where Protocols Meet Performance
TriNetX LIVE™—the world’s most comprehensive federated real-world data (RWD) network—bridges the gap between trial design and execution. Powered by advanced RWD analytics, the TriNetX LIVE™ platform empowers trial teams to:
Accelerate Design-to-Recruitment
Rapidly pinpoint optimal sites and eligible patients to reduce delays and enhance trial precision.
TriNetX Impact: Cut design cycles and amendments by 20%+
Execute with Confidence
Align study protocols with real-world patient availability at activation-ready sites for faster, more reliable trial execution.
TriNetX Impact: Identify 50%+ more sites with eligible patient populations.
Expand Access, Amplify Impact
Reach underserved communities and reduce non-enrolling sites to boost inclusivity and ROI.
TriNetX Impact: Reduce non-enrolling sites by ~20%, saving $100K–$200K per site.
TriNetX LIVE™ in Action: From Data to Delivery

Search
Access a global RWD network across 29+ countries and 300M+ de-identified patients, with 10–12 years of longitudinal data on average.

Match
Identify eligible patients today and prioritize sites based on actual availability.

Activate
Engage protocol-aligned sites to launch trials with greater speed.
Proof in Performance: Real-World Success Stories
Smarter Recruitment in Autoimmune Trials
A lupus study team utilized TriNetX RWD to overcome high screen failure rates. By proactively identifying eligible patients and refining pre-screening, they improved engagement and recruitment in a historically challenging area.
Boosting Myeloma Trial Enrollment
Faced with slow, manual recruitment processes in myeloma trials, a research team turned to TriNetX to streamline patient identification. Leveraging real-time data, they rapidly improved screening efficiency, accelerated enrollment, and expanded trial access for patients—including those with rare disease subtypes.
Ready to Future-Proof Your Trial Execution?
TriNetX transforms clinical trials by connecting protocol strategy to real-world performance—reducing delays, eliminating waste, and maximizing ROI. Run your next trial faster, smarter, and more cost-effectively.
More in our eBook, Bridging the Last Mile: A Guide to Utilizing Real-World Data in the Final Stretch of Clinical Trials

References for the Data within “The Hidden Cost of Misaligned Trial Design”:
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