From Protocol Design to Execution: How Real-World Data Accelerates Clinical Trial Completion - TriNetX

From Protocol Design to Execution: How Real-World Data Accelerates Clinical Trial Completion

Thursday, Jul 10

Written by TriNetX

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Discover how Real-World Data Accelerates Clinical Trial Completion

Clinical trials often falter at the final stretch—when it’s time to execute. It’s here that well-intentioned protocols meet real-world complexity, where timelines can slip, costs may surge, and outcomes could fall short of expectations.

The Hidden Cost of Misaligned Trial Design

%

Of protocols undergo at least one substantial amendment

Of these amendments are deemed “avoidable”

%

Median direct cost to implement a substantial amendment for a phase III protocol

TriNetX: Where Protocols Meet Performance

TriNetX LIVE™—the world’s most comprehensive federated real-world data (RWD) network—bridges the gap between trial design and execution. Powered by advanced RWD analytics, the TriNetX LIVE™ platform empowers trial teams to:

Accelerate Design-to-Recruitment

Rapidly pinpoint optimal sites and eligible patients to reduce delays and enhance trial precision.

TriNetX Impact: Cut design cycles and amendments by 20%+

Execute with Confidence

Align study protocols with real-world patient availability at activation-ready sites for faster, more reliable trial execution.

TriNetX Impact: Identify 50%+ more sites with eligible patient populations.

Expand Access, Amplify Impact

Reach underserved communities and reduce non-enrolling sites to boost inclusivity and ROI.

TriNetX Impact: Reduce non-enrolling sites by ~20%, saving $100K–$200K per site.

TriNetX LIVE™ in Action: From Data to Delivery

Search

Access a global RWD network across 29+ countries and 300M+ de-identified patients, with 10–12 years of longitudinal data on average.

Match

Identify eligible patients today and prioritize sites based on actual availability.

Activate

Engage protocol-aligned sites to launch trials with greater speed.

Proof in Performance: Real-World Success Stories

Smarter Recruitment in Autoimmune Trials

A lupus study team utilized TriNetX RWD to overcome high screen failure rates. By proactively identifying eligible patients and refining pre-screening, they improved engagement and recruitment in a historically challenging area.

Boosting Myeloma Trial Enrollment

Faced with slow, manual recruitment processes in myeloma trials, a research team turned to TriNetX to streamline patient identification. Leveraging real-time data, they rapidly improved screening efficiency, accelerated enrollment, and expanded trial access for patients—including those with rare disease subtypes.

Ready to Future-Proof Your Trial Execution?

TriNetX transforms clinical trials by connecting protocol strategy to real-world performance—reducing delays, eliminating waste, and maximizing ROI. Run your next trial faster, smarter, and more cost-effectively.

More in our eBook, Bridging the Last Mile: A Guide to Utilizing Real-World Data in the Final Stretch of Clinical Trials

References for the Data within “The Hidden Cost of Misaligned Trial Design”:

2 Ibid
3 Based on a 2016 estimate of $535,000 (https://pubmed.ncbi.nlm.nih.gov/30227022/), adjusted for inflation to 2024 dollars using the Sage Inflation Calculator https://sagecalculator.com/historical-inflation-rate-calculator/

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