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Advanced Analytics

Explore patient counts in even greater detail with powerful, evidence-ready insights.

Deeper understanding. Smarter decisions.

Having the clearest picture possible of your cohort is key to designing patient-centric trials that enroll faster and retain participants.

With its extensive suite of powerful tools, TriNetX LIVE™ Advanced Analytics dives even deeper into our global real-world data network, offering the most detailed insights possible on your patient population.

Whether you’re examining treatment journeys within a given cohort or comparing outcomes between two cohorts of interest, Advanced Analytics delivers incredible results in minutes — all with zero data munging or coding required.

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How can it help you?

Explore the Advanced Analytics tools that deliver deeper cohort insight.

Advanced explore cohort

Review the clinical characteristics of your cohort across any time window you define relative to an index event, including intervals prior to that event.

  • Measure the prevalence of diagnoses and treatments just prior to, or immediately following, a clinical event of interest.  
  • Understand the health of a potential trial population at baseline.
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Analyze outcomes

Calculate overall risk and time-to-event for any observation or outcome of interest. Generate Kaplan-Meier curves, post-index lab distributions, and patient histograms by the number of times the outcome was observed.​

  • Guide endpoint selection by understanding real-world timing and frequency of outcomes​.
  • Improve study design and forecast study duration based on predicted event accumulation.
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Compare cohorts

For any two cohorts defined on the same network, compare the prevalence of diagnoses, procedures, and medications, as well as differences in lab value ranges, means, and variance.

  • Evaluate differences between potential study populations​.
  • Compare thousands of clinical characteristics along sex, age, race, and ethnicity strata.
  • Quickly compare fill rates for labs of interest.
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Compare outcomes

For any two cohorts and index events defined on the same network, calculate the absolute and relative risk of one or more outcomes. Compare hazard ratios, outcome frequencies, and post-index lab distributions.

  • Get fast, directional answers to questions of comparative safety and efficacy​.
  • Compare expected outcomes for two potential study populations.
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Incidence and prevalence

Calculate incidence, incidence rate, and prevalence across multiple timeframes simultaneously, automatically stratified by age bracket, sex, race, and ethnicity.

  • Compare prevalence and incidence along several demographic strata.
  • Uncover trends over time.
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Treatment pathways

For any cohort and index event, select medications and procedures of interest to plot their overall utilization, order of administration, and treatment duration.

  • Identify standards of care​.
  • Monitor utilization of new treatments.
  • Explore switching patterns.
  • Select comparators for your study or forecast when patients will end regimens required by your protocol.
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Competing risks

For any cohort and index event, quantify the probability of a patient experiencing each one of several mutually exclusive outcomes.

  • Isolate risks for each of several adverse events in response to a medication​.
  • Better understand the causes of death post-index​.
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Want to learn more?

Explore our latest articles, news, and whitepapers.

The Real-World Data Advantage: Why Clinical Operations Teams are Rethinking AI Strategy
eBooks
The Real-World Data Advantage: Why Clinical Operations Teams are Rethinking AI Strategy

Download our latest eBook to learn how TriNetX is combining the world’s largest RWD network with advanced AI to accelerate protocol design, site selection, and patient recruitment.

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Blogs
TriNetX Wins the Clinical Trial Innovation Award (and What It Means for the Future of Research)

We are honored to share that TriNetX has won the “Clinical Trial Innovation Award” in the 10th annual MedTech Breakthrough Awards.

TriNetX® Wins “Clinical Trial Innovation Award” in 10th Annual MedTech Breakthrough Awards Program
Press Releases
TriNetX® Wins “Clinical Trial Innovation Award” in 10th Annual MedTech Breakthrough Awards Program

Landmark 10th Annual Awards Program Recognizes the Most Innovative Digital Health and Medical Technology Solutions Worldwide. [External]

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Case Studies
Global Pharma Organization Accelerates Study Design Decisions by Embedding RWD and AI Earlier in Trial Planning

By partnering with TriNetX, one global pharma organization embedded real‑world data and transparent AI‑enabled query translation directly into existing design workflows.

Powering Clinical Research Innovation: How TriNetX Uses Databricks to Accelerate Drug Development
Blogs
Powering Clinical Research Innovation: How TriNetX Uses Databricks to Accelerate Drug Development

Clinical development costs now average roughly $708 million per approved therapy. The industry’s need for accessible and trustworthy insight from real‑world data has never been greater.

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Blogs
What Makes Real-World Evidence Credible? Insights from Academic Research

We spotlight Tasfia’s work at Penn State and distilling practical lessons for other researchers navigating the complexities of cohort-based RWE studies.

TriNetX Enhances its Ability to Federate Genomics Data Across its Global Network of Providers through the Acquisition of Key Assets of Zetta Genomics
Press Releases
TriNetX Enhances its Ability to Federate Genomics Data Across its Global Network of Providers through the Acquisition of Key Assets of Zetta Genomics

TriNetX, the world’s leading federated health data network, today announced that it has acquired the key assets of Zetta Genomics, a Cambridge, UK-based healthcare technology company and current TriNetX partner.

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Press Releases
Regeneron Collaborates with TriNetX to Access De-Identified Electronic Health Records of 300 Million Patients to Drive Research and Product Development in Life Sciences and Digital Health Solutions

Regeneron Pharmaceuticals, Inc. and TriNetX® today announced a strategic collaboration to support Regeneron’s capabilities in drug discovery and development, as well as new initiatives to deliver digital health solutions of the future for consumers, patients and providers.

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Webinars
Smarter Trial Decisions Through Clinical Data Integration

We explore how clinical data integration unifies disparate systems to deliver actionable insights.

Patient-Centricity at the Point of Care: A Clinician’s Perspective on Rethinking Trials
Blogs
Patient-Centricity at the Point of Care: A Clinician’s Perspective on Rethinking Trials

In our latest Inside the Trends vodcast episode, COO Steve Kundrot spoke with Dr. Sarju Ganatra , a cardiologist and Co-Director of the Lahey Innovation Hub. They stripped patient-centricity back to its core.

TriNetX Named Best of Show Finalist at SCOPE
Blogs
TriNetX Named Best of Show Finalist at SCOPE

TriNetX is proud to announce that we were named a Best of Show Finalist at SCOPE, the summit for clinical ops executives, one of the industry’s premier events focused on advancing clinical operations and innovation.

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Inside the Trends
Insights from the Healthcare System for Patient-Centric Trials at the Point of Care

Patient-centricity is everywhere in clinical research. But what does it actually look like inside real healthcare systems?

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Press Releases
TriNetX Unveils Conversational AI Interface and Enhanced API Capabilities

Success achieved in reducing trial costs and timelines drives 2026 platform enhancements designed to democratize clinical research analytics.

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Blogs
The Year Real-World Data Became Essential: The Resources That Captivated Our Community in 2025

As we step into 2026, explore the resources that captivated our community in 2025, and more importantly, why they mattered.

Winning with RWE: What It Takes to Make Real-World Evidence Submission-Ready
Blogs
Winning with RWE: What It Takes to Make Real-World Evidence Submission-Ready

In the 2025 TriNetX and studioID survey of 150 senior biopharma executives, all participants agreed that real-world evidence has the potential to improve regulatory submissions, underscoring the urgency for sponsors to integrate RWE more strategically into their regulatory playbooks.

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Blogs
Three Recognitions, One Mission: Accelerating Innovation Across the Global Healthcare Ecosystem

As 2025 wraps up, the TriNetX team is reflecting on a year of milestones, among them, being named to The Healthcare Technology Report’s Top 50 Healthcare Technology Companies list this November.

Survey Confirms: RWD and AI Are Now Mission-Critical Infrastructure for Biotechs
Blogs
Survey Confirms: RWD and AI Are Now Mission-Critical Infrastructure for Biotechs

To succeed, biotechs are rethinking how clinical research gets done. RWD, AI, and patient-centric strategies are no longer experimental; they’re emerging as the core toolkit for companies determined to accelerate progress while controlling risk.

Turn Real-World Data Complexity Into Clarity With AI
Webinars
Turn Real-World Data Complexity Into Clarity With AI

Real-world data (RWD) plays a crucial role in clinical research and decision-making, yet navigating its complexity remains a significant challenge. RWD typically comes from claims—open or closed—or from electronic health records (EHRs).

Proof in Publications – The Most Cited. The Most Trusted. TriNetX Real-World Data
Blogs
Proof in Publications – The Most Cited. The Most Trusted. TriNetX Real-World Data

Discover why TriNetX is the most-cited EHR dataset in peer-reviewed publications. Explore how our high-quality real-world data (RWD) powers high-impact research in top-tier medical journals and drives global breakthroughs in real-world evidence.

Clinical Trial Optimization: Key Strategies for Protocol Feasibility and Site Selection
Blogs
Clinical Trial Optimization: Key Strategies for Protocol Feasibility and Site Selection

Clinical trials are the cornerstone of medical advancements, playing a pivotal role in the development of new treatments, interventions and understanding of diseases.

Putting Patients First: A Conversation with Ora on the Future of Clinical Trials
Blogs
Putting Patients First: A Conversation with Ora on the Future of Clinical Trials

In my role at TriNetX, I have the privilege of engaging with leaders across the clinical research landscape who are challenging the status quo and pushing us toward a more inclusive, tech-enabled, and patient-first future.

Biotech Playbook
eBooks
Biotech Playbook

The clinical research landscape is evolving, and the demand for faster, more efficient trials has never been greater. From restrictive protocols, fragmented processes, and a never-ending amendment cycles.

Care Reimagined: The Shift Toward Patient-Centric Research
Inside the Trends
Care Reimagined: The Shift Toward Patient-Centric Research

What happens when clinical research is redesigned around the needs, preferences, and lives of real people? In this episode of The Future Prescription: Inside the Trends, discover how sponsors and CROs are aligning clinical and commercial priorities to create smarter, more inclusive, and scalable studies.

Inclusion Is the New Standard: Biopharma’s Push for More Representative Clinical Trials
Blogs
Inclusion Is the New Standard: Biopharma’s Push for More Representative Clinical Trials

As clinical trials evolve, one thing is certain: representativeness is no longer a nice-to-have; it’s a non-negotiable. The data are clear. In the 2025 TriNetX and studioID survey of 150 senior biopharma executives, 84% reported ramping up efforts to improve representativeness and accessibility in clinical research over the past few years.

Sanofi UK and Royal Berkshire NHS Foundation Trust Optimize Clinical Trial Recruitment with Technology-Driven Feasibility and Site Selection Process
Case Studies
Sanofi UK and Royal Berkshire NHS Foundation Trust Optimize Clinical Trial Recruitment with Technology-Driven Feasibility and Site Selection Process

Sanofi UK, a leading pharmaceutical company, sought an innovative solution to address challenges in clinical trial recruitment and feasibility.

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Blogs
From Buzz to Breakthrough: How Biopharma Is Embedding Real-World Data into Drug Development

In just a few years, real-world data (RWD) has evolved from an industry buzzword to a core driver of progress in drug development. What used to be experimental is now operational and increasingly essential. In the 2025 TriNetX and studioID survey of 150 senior biopharma executives, more than three-quarters said their organizations are already applying RWD across some part of the drug development lifecycle. We’re clearly well beyond the pilot phase.

New TriNetX Research Impact Report Illuminates How Real-World Data is Fueling Rare Disease Innovation
Press Releases
New TriNetX Research Impact Report Illuminates How Real-World Data is Fueling Rare Disease Innovation

Analysis reveals strategic opportunities for pharmaceutical leaders to close treatment gaps and accelerate breakthroughs in underserved rare disease communities.

New TriNetX Survey Reveals Biopharma’s Bold Embrace of Real-World Data and Artificial Intelligence—But Warns of Looming Barriers
Press Releases
New TriNetX Survey Reveals Biopharma’s Bold Embrace of Real-World Data and Artificial Intelligence—But Warns of Looming Barriers

Real-world data (RWD), artificial intelligence (AI), and patient-centric trial design lead pharma priorities in 2025, but data compatibility, regulatory hurdles, and security concerns threaten to stall momentum.

From Protocol Design to Execution: How Real-World Data Accelerates Clinical Trial Completion
Blogs
From Protocol Design to Execution: How Real-World Data Accelerates Clinical Trial Completion

Clinical trials often falter at the final stretch—when it’s time to execute. It’s here that well-intentioned protocols meet real-world complexity, where timelines can slip, costs may surge, and outcomes could fall short of expectations.

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Blogs
Cracking the Code on the Last Mile: A Three-Step Process for Clinical Trial Success

In the high-stakes world of clinical research, innovation doesn’t just happen in the lab; it must cross the clinical trial finish line of regulatory submission. Yet for many sponsors, sites, and researchers, patient recruitment—or the “last mile”—remains a costly bottleneck where recruitment can lag, site enrollment can underperform, and promising treatments never receive approval.

Bridging the Last Mile of Clinical Trials
eBooks
Bridging the Last Mile of Clinical Trials

The “last mile” of clinical research represents the crucial phase where protocols are put into action, and patient engagement becomes a reality. It’s about transforming well-laid plans into meaningful outcomes by efficiently connecting researchers, sites, and participants.

Glowing jellyfish close-up in the aquarium blue color.
Blogs
Five Game-Changing Trends: How Real-World Data Is Impacting Clinical Research

Clinical trials are being reinvented by real-world data (RWD). In 2025, data-driven strategies won’t just complement trial design—they’ll define it. From protocol optimization to accelerated site identification, data is the new compass guiding clinical innovation

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Blogs
Real-World Data and Artificial Intelligence: Solving Key Clinical Trial Challenges

The result? Higher costs, longer timelines, and compromised outcomes. The need to solve these critical challenges has never been more urgent.

No More Data Silos: How TriNetX Uses Real-World Data to Pinpoint the Best Clinical Trial Sites
Blogs
No More Data Silos: How TriNetX Uses Real-World Data to Pinpoint the Best Clinical Trial Sites

Combining disparate data sources to inform clinical trial site selection has long been a complex challenge. Inconsistent site naming, differences in the definition of a site, and a lack of potential patient counts, among other obstacles, have made it difficult for sponsors to pinpoint optimal sites.  

Unlock the Power of Harmonized Global Real-World Data: 5 Reasons to Partner with TriNetX
Blogs
Unlock the Power of Harmonized Global Real-World Data: 5 Reasons to Partner with TriNetX

Real-world data (RWD) and the real-world evidence (RWE) derived from analysis of the data are a cornerstone of clinical advancements in today’s fast-paced research environment

Rewriting the Rules of Clinical Research with Real-World Data: 5 Shifts You Can’t Afford to Ignore
Blogs
Rewriting the Rules of Clinical Research with Real-World Data: 5 Shifts You Can’t Afford to Ignore

The healthcare and clinical research industries are undergoing a seismic shift. Rapid advancements in real-world data (RWD), artificial intelligence (AI), and patient-centric approaches are rewriting the playbook for clinical trials and treatment development. The future of healthcare is here, and organizations that embrace these changes will be at the forefront of innovation. 

CRO Achieves Rapid Response, Increased Acceptance Rate Via Data-Driven Clinical Trial Site ID and Outreach Approach
Case Studies
CRO Achieves Rapid Response, Increased Acceptance Rate Via Data-Driven Clinical Trial Site ID and Outreach Approach

Clinical trial site identification (ID) and outreach are often inefficient due to manual, paper-based processes, placing a heavy burden on both contract research organizations (CROs) and the clinical study sites with which they work.

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Blogs
Artificial Intelligence and Real-World Data: Speeding Up Drug Development Like Never Before

Clinical trials are vital to drug development but often face challenges such as slow patient recruitment, high costs, and suboptimal trial designs. Today, artificial intelligence (AI) and real-world data (RWD) are transforming this process by optimizing trial protocols, enhancing recruitment, and accelerating timelines.  

Overcoming Challenges in Clinical Trial Completion
Webinars
Overcoming Challenges in Clinical Trial Completion

Clinical trials are the backbone of medical advancements, yet they often face significant hurdles in their final stages.

Diversity in Clinical Trials: The Ethical and Scientific Imperative to Bridge Health Disparities
Blogs
Diversity in Clinical Trials: The Ethical and Scientific Imperative to Bridge Health Disparities

In the evolving landscape of clinical research, the era of one-size-fits-all clinical trials is firmly behind us. Regulatory bodies and industry leaders alike recognize the necessity of diverse representation in trials to ensure that medical treatments are effective for all populations.

Digital Waiting Rooms: Powering the Last Mile of Clinical Research with Real-World Data and Artificial Intelligence
Blogs
Digital Waiting Rooms: Powering the Last Mile of Clinical Research with Real-World Data and Artificial Intelligence

The integration of digital technology is transforming clinical research, improving the efficiency of trial design and execution. A key innovation in this space is the digital waiting room, which leverages real-world data (RWD) and artificial intelligence (AI) to enhance the critical “last mile” of a trial—when sites are activated, and patient recruitment begins. 

Breaking Down SCOPE 2025: What’s Next for Clinical Trials?
Blogs
Breaking Down SCOPE 2025: What’s Next for Clinical Trials?

SCOPE 2025, held from February 3-6 in Orlando, Florida, brought together over 4,500 leaders in clinical operations and research to discuss the latest advancements in clinical trial innovation, planning, management, and operations

TriNetX and Fujitsu Launch Joint Venture to Increase Japanese Patients’ Access to Life-Changing Medicines
Press Releases
TriNetX and Fujitsu Launch Joint Venture to Increase Japanese Patients’ Access to Life-Changing Medicines

Partnership taps real-world data to accelerate clinical trials, research, and drug development in Japan.   

The Impact of Responsible AI on Healthcare: Challenges and Opportunities Ahead
Blogs
The Impact of Responsible AI on Healthcare: Challenges and Opportunities Ahead

In a rapidly evolving healthcare landscape, artificial intelligence (AI) is emerging as a transformative force in drug development and clinical research. With the average cost of bringing a new drug to market soaring to $1.3 billion and a low probability of success, the stakes for innovation have never been higher.

SCOPE 2025: Putting Patients at the Heart of Research
Blogs
SCOPE 2025: Putting Patients at the Heart of Research

Clinical trials are the bedrock of medical advancement, but they often grapple with a persistent challenge: ensuring diverse and representative participation. This issue isn’t just a matter of ethics—it’s crucial for delivering effective, equitable healthcare solutions.   

TriNetX’s Founding CEO Announces Plans to Step Down
Press Releases
TriNetX’s Founding CEO Announces Plans to Step Down

After 11 Years, Gadi Lachman to Conclude Operating Role, Remain on TriNetX’s Board

Revolutionizing Research and Clinical Trials: Innovating Today for a Healthier Tomorrow
Blogs
Revolutionizing Research and Clinical Trials: Innovating Today for a Healthier Tomorrow

In an era defined by rapid advancements in technology and science, healthcare research and clinical trials are undergoing a transformative shift. At the heart of this revolution is data—vast, diverse, and ever-growing—and the collaborative efforts of stakeholders across the healthcare ecosystem.

With new diversity guidance, EHR data plus AI will be critical
Blogs
With new diversity guidance, EHR data plus AI will be critical

In June 2024, the U.S. Food and Drug Administration (FDA) issued draft guidance outlining the need for “Diversity Action Plans” as a way for clinical trial sponsors to demonstrate their consideration toward trial representation

Optimizing Cancer Clinical Trials with External Control Arms
Blogs
Optimizing Cancer Clinical Trials with External Control Arms

Cancer clinical trials have long been the cornerstone of advancements in oncology, guiding the development of new therapies and improving patient outcomes.

Artificial Intelligence for the Good of Healthcare
eBooks
Artificial Intelligence for the Good of Healthcare

Artificial intelligence (AI) has the potential to revolutionize drug development by leveraging real-world data (RWD) from electronic health records, claims data, patient registries, and wearable devices.

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Webinars
RWD to the Rescue: Solving R&D Challenges for Pharma Companies

Discover an insightful webinar that focuses on the transformative potential of real-world data (RWD) in clinical research and healthcare strategy.

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Blogs
Turning Clinical Trial Site Selection on its Head: A Bold New Approach

The landscape of clinical trials is evolving, and with it, the approach to site selection. A more patient-centric model is emerging, which flips the traditional process on its head.  

TriNetX Achieves Spain’s ENS Certification for Rigorous Healthcare Data Security Standards
Press Releases
TriNetX Achieves Spain’s ENS Certification for Rigorous Healthcare Data Security Standards

Company recognized with high-level certification for abiding by Spain’s strongest data security measures, sets a new standard for healthcare data protection within its TriNetX LIVE™ platform.

From Informative to Transformative: How Real-World Data is Fueling Healthcare Innovation
Blogs
From Informative to Transformative: How Real-World Data is Fueling Healthcare Innovation

Gadi Lachman, President and CEO of TriNetX, discussed the profound impact RWD is having on the healthcare industry in a Crossroads by Alantra podcast episode — Unlocking the Power of Real-World Data — released earlier this month.

Equity in Action: Data-Driven Strategies to Advance Diversity in Clinical Trials
Blogs
Equity in Action: Data-Driven Strategies to Advance Diversity in Clinical Trials

“Diversity in clinical trials” is undoubtedly one of the hottest topics in the healthcare industry today and with good reason. Underrepresentation in clinical trials can have significant and wide-ranging consequences

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Webinars
Diversity in Clinical Trials

Join us for an insightful webinar that delves into the critical topic of diversity in clinical trials. This event explores using real-world data (RWD) to enhance trial design, promote health equity, and foster robust evidence generation.

Real-World Data To Improve Clinical Trial Design
Blogs
Real-World Data To Improve Clinical Trial Design

Many clinical trials struggle to enroll patients, hindering meaningful results and delaying the delivery of therapies to patients. Real-world data (RWD) addresses this by overcoming barriers such as overly strict enrollment criteria and disconnects between research design and patients’ lived experiences.

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Blogs
Growing Need for Diversity in Clinical Trials

Earlier this year, the FDA rejected an application for a new cancer drug because it was based on a trial conducted in China, and the agency ruled it did not represent the U.S. population.

East Lancashire Hospitals NHS Trust Leverages TriNetX to Automate Research Capabilities and Optimize Clinical Trial Patient Recruitment
Case Studies
East Lancashire Hospitals NHS Trust Leverages TriNetX to Automate Research Capabilities and Optimize Clinical Trial Patient Recruitment

East Lancashire Hospitals NHS Trust (ELHT) is a large, integrated healthcare organization providing high quality acute secondary healthcare for more than 700,000 people of East Lancashire and Blackburn annually.

TriNetX Helps Cuyahoga County’s MetroHealth System in Ohio Strive for Clinical Research Leadership Through Data Sharing
Case Studies
TriNetX Helps Cuyahoga County’s MetroHealth System in Ohio Strive for Clinical Research Leadership Through Data Sharing

The MetroHealth System, Cuyahoga County’s public health system, provides care to more than 300,000 patients through nearly 1.5 million visits a year at its four hospitals, and more than 20 health centers throughout the county, which includes Cleveland and surrounding suburbs

Enhancing Research Studies, Increasing Clinical Trial Opportunities at West Virginia Clinical and Translational Science Institute
Case Studies
Enhancing Research Studies, Increasing Clinical Trial Opportunities at West Virginia Clinical and Translational Science Institute

The West Virginia Clinical and Translational Science Institute (WVCTSI), a partner of West Virginia University (WVU), is an academic home and a catalyst for clinical and translational research that targets priority health areas including addiction and resulting emerging epidemics such as hepatitis C, cancer, cardiovascular disease, and chronic lung disease.

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