External Control Arms
Build smarter control groups with fit-for-purpose real-world patient cohorts.
Shorter timelines. Stronger evidence.
Based on a proven methodology built upon 30+ years of experience, TriNetX external control arms (ECAs) help you with timely, representative, granular, and fit-for-purpose control groups.
Designed for studies where randomized controls are impractical, our experts will guide you through set-up, regulations, and execution as we use real-world patient data in lieu of additional patient recruitment, reducing costs and timelines while generating robust, regulation-ready evidence to support your trial.
Navigate regulatory uncertainty with confidence
Strengthen your HTA and EMA submissions with representative, fit-for-purpose ECAs designed for regulatory readiness.
Our methodology ensures scientifically sound data and processes, delivering evidence that regulators can trust and increasing your chances of a successful submission.
Overcome data and implementation challenges
TriNetX ECAs maintain the integrity of your analyses and results while helping you gain deeper insights into treatment impact. You can even generate supplementary control information for prospective experimental arms.
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Explore our insights
The clinical trial industry has made a significant bet on artificial intelligence. The investment has been substantial. The results have been harder to quantify.
The TriNetX LIVE™ network has crossed 300 million patients across 240+ healthcare organizations and 13,000+ sites.
Jeff Brown recently took the podium at ISPOR 2026 to share how we, as a community, can use real-world data to generate robust and actionable evidence.
Run time: 7mins. Big data isn’t always the right data. In this video, learn how to assess whether a dataset is truly fit for your research question, because data fitness is about the right elements for the right cohort, not dataset size or reputation.
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