One Condition, Many Definitions: How Context Shapes Every Variable

In real-world data research, there is no single, universal definition for a clinical concept. The same condition can mean something entirely different depending on the study question, data source, and country. Getting definitions right isn’t an operational detail; it’s the foundation of credible, regulatory-grade evidence.

In this video, you’ll learn:

• Why small differences in how clinical concepts are defined can significantly change cohort sizes, outcome capture, and study results — and how to spot these risks before they compromise your research
• How to build harmonized, fit-for-purpose variable definitions across health systems, EHR platforms, and countries — including when to use multicomponent definitions, sensitivity analyses, and phenotype validation studies
• Why context determines everything in RWD variable definition, and what it takes to document and defend your definitional choices to regulators, publications committees, and other key stakeholders