TriNetX Global Real-World Data Network
TriNetX connects researchers, clinicians, and innovators to the broadest federated network of real-world health data available — with the integrity to act on it. It’s the only real-world data network built with healthcare providers, not around them.
The TriNetX network doesn't just hold data. It drives discovery.
The true measure of a data network isn't the records it contains—it's what those records have made possible. TriNetX-powered research has accelerated drug development, informed regulatory decisions, and generated the evidence that moves healthcare forward.
patient lives
clinical data points
clinical sites
countries worldwide
peer-reviewed publications
total linkable patients
Independently Recognized. Rigorously Certified.
Industry awards and global security certification — because trust has to be earned.
Every conclusion is only as strong as the network beneath it.
The wrong data network doesn’t just slow you down. It undermines everything built on it—every finding, every submission, every decision that flows from data you couldn’t fully trust. Anyone can aggregate data. What TriNetX has built is fundamentally different and supports a network designed to remain steadfast through the test of time.
Our federated network model means patient data never leaves the walls of the healthcare organizations that generate it. No central repository. No data transfers. No compromises on security or compliance.
Instead, queries travel to the data. Our TriNetX LIVE™ platform accelerates users to insights that your team can trust completely.
Patient-level data never leaves the source system. Federated queries run locally at the point of care and return only aggregate insights—giving you full regulatory confidence across every market you operate in.
Healthcare providers spanning academic medical centers, community hospitals, integrated delivery networks, and speciality clinics across six continents deliver population-level insight that reflects the full diversity of real-world patients—not just the closest ones to your headquarters.
Every record originates from a real patient encounter—diagnoses, procedures, labs, medications, genomics. Structured EHR data, standardized and analysis-ready. The kind of data your conclusions can be built on.
Ten years of relationships you can't replicate overnight.
Our network isn’t a product feature—it’s the result of a decade of earned trust with the world’s leading healthcare organizations. Every partner chose TriNetX because of a shared belief: that when data is handled with integrity, it can change the course of patient care.
We’ve built our network one relationship at a time—listening to the needs of healthcare providers, aligning with their governance requirements, and designing technology that fits into their workflows, not over them. The result is a network that grows stronger with every partner we add and every query that runs.
What makes TriNetX a partner, not just a platform
- Dedicated partner success teams
- Flexible governance frameworks
- No data extraction required
- GDPR & HIPAA aligned
- IRB and ethics board support
- OMOP & common data model ready
- Ongoing data quality programs
- Continuous network expansion
Built for every stakeholder in the health research ecosystem.
TriNetX Global Real-World Data Accelerates Innovation
The same network. The same standard of data. Powering different outcomes for every type of user.
Life Sciences
See the network in action.
Request a personalized demo and explore what the TriNetX platform can deliver for your specific research questions.
Compress timelines. Expand confidence.
From patient identification to post-approval surveillance, access the patient populations and clinical evidence you need—without months of data access negotiations.
Find the right sites. Faster.
Identify trial-ready sites with the patient populations to make your study succeed. Reduce feasibility timelines from months to days with real eligibility data—not estimates.
Healthcare Organizations
Benchmark. Compare. Improve.
Use the network to benchmark your patient outcomes against comparable institutions globally. Understand how your population differs, where care gaps exist, and what the evidence says about the interventions that close them.
Your data, working harder for you—without leaving your walls.
Join a network that amplifies the value of data you already generate. Enable benchmarking, research collaboration, and new revenue streams—without adding burden to your clinical teams or compromising patient privacy.
Ask bigger questions.
Power hypothesis generation, observational studies, and epidemiological research with global patient populations that no single institution could achieve alone. Publish with confidence in the provenance of your data.
Scale your research footprint. Deepen your impact.
TriNetX gives large health systems the infrastructure to participate in multi-site research at scale—with governance controls, data quality programs, and partnership support designed for complex organizations.
Data Innovation Consumers
Leave the guesswork behind.
Building in health requires data that goes deeper than claims and further than synthetic. TriNetX gives data innovators direct access to real structure clinical data from hundreds of millions of patient records—rigorously standardized, globally diverse, and built on a decade of healthcare partnerships.
Answers at the scale your questions deserve.
Access a standardized, analytics-ready data environment without building your own infrastructure. Query globally. Analyze locally. Act with confidence.
Investors ask. Regulators ask. Enterprise buyers ask. Now you have an answer.
The question every health tech company eventually faces is the same: what’s your data source, how do you know it is right? TriNetX gives digital health companies access to real structured clinical data—not claims approximations, not synthetic datasets. Form the TriNetX RWD Network, this is the kind of data that holds up when it matters most.
A model is only as generalizable as the data it learned from.
The clinical AI field is full of models that perform brilliantly in validation and fail quietly in deployment. When trained on a single health system, test on that system’s patients, and never exposed to the population diversity that real-world performance demands, it’s obvious AI models need better data.
TriNetX changes that equation. With hundreds of millions of patients across multiple continents and countries, standardized to common ontologies, with full provenance documentation, you can train on clinical reality and deploy with confidence.
Better. Faster. Unmatched Quality.
Research Integrity isn’t a feature. It’s the foundation at TriNetX.
When decisions affect patients, the quality of the underlying data matters more than the speed of the query. TriNetX was built with that principle at its core. Our network undergoes continuous data quality validation, standardization to OMOP and other common data models, and rigorous curation processes—ensuring what you’re analyzing reflects what actually happened at the clinic.
Data across all network partners is mapped to a common data ontologies—ICD, SNOMED, LOINC, RxNorm—ensuring that a query run in Tokyo returns results directly comparable to one run in Toronto.
Know exactly which organizations contributed to your cohort, how data was collected, and how it was transformed. Full lineage. Full confidence in every finding you produce.
Automated quality checks and ongoing partner data programs ensure the network you query today reflects the standards your research demands—not data that was validated once and forgotten.
TriNetX’s federated architecture, standardized data models, and documented provenance mean your methodology holds up—in a peer-review process, a regulatory submission, or a boardroom presentation.
3,600+ peer-reviewed publications cite TriNetX as their data source.
When you build on TriNetX, your methodology is defensible from day one—validated by the research community that has already staked its credibility on this network. See the proof in publications at PubMed®.
Data-driven insights
Big data isn’t always the right data. Learn how to assess whether a dataset is truly fit for your research question, because data fitness is about the right elements for the right cohort, not dataset size or reputation.
EHR data is one of the richest sources for real-world research, but it was never actually designed for it. This video covers the opportunities, the pitfalls, and the mindset needed to get the most out of it.
Misaligned definitions don’t just complicate analysis; they produce misleading results. Learn why harmonized definitions are essential for multi-site RWD studies and what it takes to make them stand up to scientific and regulatory scrutiny.
At ISPOR 2026, we presented posters addressing outcomes in relapsed/refractory DLBCL, and introducing a reproducible method for generating population estimates robust enough to stand up in HTA and regulatory submissions.
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